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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Monitoring therapeutic efficacy in a mouse lung-cancer model by <t>using</t> <t>μCT</t> imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images <t>(2D</t> and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.
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Image Search Results


Monitoring therapeutic efficacy in a mouse lung-cancer model by using μCT imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images (2D and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.

Journal: Comparative Medicine

Article Title: Contrast Agents for Quantitative MicroCT of Lung Tumors in Mice

doi:

Figure Lengend Snippet: Monitoring therapeutic efficacy in a mouse lung-cancer model by using μCT imaging. EML4–ALK mice treated with crizotinib (100 mg/kg daily) for 7 d demonstrated marked reduction in tumor size according to μCT imaging. (A) Pre- and posttreatment μCT images (2D and 3D views) are shown; arrows indicate the tumor nodules depicted in both the 2D and 3D views. (B) Relative comparison (before and after treatment) of tumor regression due to crizotinib therapy (n = 7 tumor nodules from 3 mice); ‡, P < 0.001.

Article Snippet: The 2D binary digital imaging communication files obtained by using a μCT evaluation program (version 6.5-1, Scanco Medical) were imported into a 64-bit (OsiriX version 3.9.2, Pixmeo, Geneva, Switzerland) for further analysis.

Techniques: Drug discovery, Imaging, Comparison